How a public health crisis nearly derailed the American Revolution

George Washington confronted a smallpox epidemic with a belief in science—and a controversial plan.

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George Washington strikes a confident pose after the victorious Battle of Princeton in this iconic portrait by Charles Willson Peale.

When American colonists launched their revolution against Britain, they quickly encountered a second but invisible enemy that threatened to wipe out the new Continental Army: highly contagious smallpox.

But luckily for the young nation, the army’s commander was familiar with this formidable foe. George Washington’s embrace of science-based medical treatments—despite stiff opposition from the Continental Congress—prevented a potentially disastrous defeat, and made him the country’s first public health advocate.

A hard lesson

Washington’s wisdom came from personal experience with the horrors of an epidemic. “Was strongly attacked by the small Pox,” Washington wrote as a teenager in 1751, while visiting the Caribbean island of Barbados. At the time, the disease caused by the variola viruskilled as many as one in two victims. Washington was lucky. After nearly a month of chills, fever, and painful pustules, he emerged with the pockmarked face typical of survivors—but alive, and with immunity to the illness.

Washington’s encounter with the virus proved fortunate for the new nation. In 1775, smallpox arrived in Boston,...

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